Maintained by Dr. Jiajie She in Longjun Wu's Lab & Pei-Yuan Qian's Lab and supported by Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) & The Hong Kong University of Science and Technology
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Genomic Location: chr7:13303932...13329452
NR annotation: XP_028516489.1, ER degradation-enhancing alpha-mannosidase-like protein 1 isoform X1 [Exaiptasia diaphana]
| CDS | |
| gene24526.t1 | |
| Transcript |
| gene24526.t1 |
| Protein |
| gene24526.t1 |
| Uniprot term | Description |
|---|---|
| Q92611 | ER degradation-enhancing alpha-mannosidase-like protein 1 OS=Homo sapiens OX=9606 GN=EDEM1 PE=1 SV=1 |
| Q925U4 | ER degradation-enhancing alpha-mannosidase-like protein 1 OS=Mus musculus OX=10090 GN=Edem1 PE=1 SV=1 |
| Q99JI4 | 26S proteasome non-ATPase regulatory subunit 6 OS=Mus musculus OX=10090 GN=Psmd6 PE=1 SV=1 |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF10602 | RPN7 | 26S proteasome subunit RPN7 | Repeat | Interproscan |
| PF01532 | Glyco_hydro_47 | Glycosyl hydrolase family 47 | Repeat | Interproscan |
| PF21154 | RPN7_PSMD6_C | 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix | Domain | Interproscan |
| PF01399 | PCI | PCI domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR045135 | Domain | 26S proteasome regulatory subunit Rpn7, N-terminal | Interproscan |
| IPR011990 | Homologous_superfamily | Tetratricopeptide-like helical domain superfamily | Interproscan |
| IPR001382 | Family | Glycoside hydrolase family 47 | Interproscan |
| IPR000717 | Domain | Proteasome component (PCI) domain | Interproscan |
| IPR036026 | Homologous_superfamily | Seven-hairpin glycosidases | Interproscan |
| IPR012341 | Homologous_superfamily | Six-hairpin glycosidase-like superfamily | Interproscan |
| IPR036390 | Homologous_superfamily | Winged helix DNA-binding domain superfamily | Interproscan |
| IPR049549 | Domain | 26S proteasome regulatory subunit RPN7/PSMD6, C-terminal helix | Interproscan |
| IPR044674 | Family | ER degradation-enhancing alpha-mannosidase-like protein 1/2/3 | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR45679 | ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 | Interproscan |
| GO terms | Category | Description | Source |
|---|---|---|---|
| GO:0005515 | Molecular Function | protein binding | Interproscan |
| GO:0004571 | Molecular Function | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | Interproscan |
| GO:0005509 | Molecular Function | calcium ion binding | Interproscan |
| GO:0016020 | Cellular Component | membrane | Interproscan |
| GO:0005975 | Biological Process | carbohydrate metabolic process | Interproscan |
| GO:0005783 | Cellular Component | endoplasmic reticulum | Interproscan |
| GO:1904380 | Biological Process | endoplasmic reticulum mannose trimming | Interproscan |
| GO:1904382 | Biological Process | mannose trimming involved in glycoprotein ERAD pathway | Interproscan |