Maintained by Dr. Jiajie She in Longjun Wu's Lab & Pei-Yuan Qian's Lab and supported by Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) & The Hong Kong University of Science and Technology
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Genomic Location: chr_11:1152123...1158305
NR annotation: XP_020917858.1, lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [Exaiptasia diaphana]
| CDS | |
| alvinactis_v1_g20986 | |
| Transcript |
| alvinactis_v1_g20986 |
| Protein |
| alvinactis_v1_g20986 |
| Uniprot term | Description |
|---|---|
| P53395 | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Mus musculus OX=10090 GN=Dbt PE=1 SV=2 |
| P11181 | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Bos taurus OX=9913 GN=DBT PE=1 SV=2 |
| P11182 | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=4 |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF02817 | E3_binding | e3 binding domain | Family | Interproscan |
| PF00198 | 2-oxoacid_dh | 2-oxoacid dehydrogenases acyltransferase (catalytic domain) | Domain | Interproscan |
| PF00364 | Biotin_lipoyl | Biotin-requiring enzyme | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR004167 | Domain | Peripheral subunit-binding domain | Interproscan |
| IPR023213 | Homologous_superfamily | Chloramphenicol acetyltransferase-like domain superfamily | Interproscan |
| IPR003016 | Binding_site | 2-oxo acid dehydrogenase, lipoyl-binding site | Interproscan |
| IPR001078 | Domain | 2-oxoacid dehydrogenase acyltransferase, catalytic domain | Interproscan |
| IPR011053 | Homologous_superfamily | Single hybrid motif | Interproscan |
| IPR000089 | Domain | Biotin/lipoyl attachment | Interproscan |
| IPR050743 | Family | 2-oxoacid dehydrogenase family, E2 component | Interproscan |
| IPR036625 | Homologous_superfamily | E3-binding domain superfamily | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR43178 | DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX | Interproscan |
| GO terms | Category | Description | Source |
|---|---|---|---|
| GO:0016746 | Molecular Function | acyltransferase activity | Interproscan |
| GO:0005737 | Cellular Component | cytoplasm | Interproscan |
| GO:0005739 | Cellular Component | mitochondrion | Interproscan |
| GO:0016407 | Molecular Function | acetyltransferase activity | Interproscan |
| GO:0031405 | Molecular Function | lipoic acid binding | Interproscan |
| KO | Enzyme | Enzyme ID | pathway | mapID | Source |
|---|---|---|---|---|---|
| K09699 | DBT, bkdB; 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) | EC:2.3.1.168 | Lipoic acid metabolism | ko00785 | deepkoala |